![]() Received: SeptemAccepted: Published: June 13, 2023Ĭopyright: © 2023 Gendron et al. Tissenbaum, University of Massachusetts Medical School, UNITED STATES PLoS Biol 21(6):Īcademic Editor: Heidi A. These data generate new insights into the neural underpinnings of how perceptive events may impact aging and physiology across taxa.Ĭitation: Gendron CM, Chakraborty TS, Duran C, Dono T, Pletcher SD (2023) Ring neurons in the Drosophila central complex act as a rheostat for sensory modulation of aging. Expression of the insulin-responsive transcription factor foxo in R2/R4 neurons and insulin-like peptides dilp3 and dilp5, but not dilp2, are required, with the latter likely altered in median neurosecretory cells (MNCs) after R2/R4 neuronal activation. In this manuscript, we demonstrate that a discrete, 5-HT2A-expressing neural population in the ellipsoid body (EB) of the Drosophila central complex, identified as R2/R4 neurons, acts as a rheostat and plays an important role in transducing sensory information about the presence of dead individuals to modulate lifespan. Previous work demonstrated that cohousing Drosophila with dead conspecifics decreases fat stores, reduces starvation resistance, and accelerates aging in a manner that requires both sight and the serotonin receptor 5-HT2A. Here, we provide new awareness into how the perception of dead conspecifics, or death perception, which elicits behavioral and physiological effects in many different species, affects lifespan in the fruit fly, Drosophila melanogaster. An understanding of the neuronal mechanisms through which animals orchestrate biological responses to relevant sensory inputs would provide insight into the control systems that may be important for modulating lifespan. Sensory perception modulates aging, yet we know little about how.
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